GNx - Giatros Nutrition Dr. FoodStop - Advanced Appetite Regulator 180 Caps

Νόμιμο συμπλήρωμα διατροφής με αριθμό γνωστοποίησης ΕΟΦ 156328/18-12-2025

DIRECTIONS OF USE.
Take 2 capsules, 30 minutes before each main meal of the day (breakfast, lunch, dinner), accompanied by 1–2 glasses of water or as directed by your doctor or pharmacist.

SUPPLEMENT FACTS.
Serving Size: 2 Capsules (3 Doses per Day)
Servings per Container: 30

	6 Caps	% NRV
Glucomannan (Konjac Root)	3000mg	**
L-Tryptophan	600mg	**
Saffron Extract (Affron®) (≥3.5% Leptrosides)	88,2mg	**
Gymnema Sylvestre Extract (≥25% Gymnemic Acids)	200mg	**
Chromium	120mg	**
* NRV = Nutrient Reference Value (EU Regulation 1169/2011). ** NRV not established.

Dr. FoodStop by Giatros Nutrition (GNx)

The FoodStop by GIATROS NUTRITION is a comprehensive appetite-regulating formula that targets the brain, gastrointestinal, and endocrine systems to control hunger, cravings, and emotional eating, while promoting satiety. Unlike appetite suppressants that are based on stimulants,Dr. FoodStop leverages the science of gastric distension, serotonin signaling, and dopaminergic modulation to naturally restore appetite control. In addition to rebalancing hunger and reward pathways, Dr. FoodStop supports healthy glucose metabolism and improves insulin sensitivity, helping to stabilize energy levels and reduce blood sugar fluctuations that can trigger cravings. Whether you're struggling with portion sizes, sugar cravings, late-night eating, or emotional hunger, this clinically grounded formula helps recalibrate your eating behavior without stress, energy crashes, or stimulant dependence

Glucomannan is a highly viscous, water-soluble dietary fiber extracted from Amorphophallus konjac. It absorbs up to 50x its weight in water, forming a gel-like matrix in the stomach that induces mechanical satiety via gastric distension and slows gastric emptying. This leads to enhanced release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), two hormones that promote fullness and reduce food intake. Glucomannan has also been shown to significantly improve fasting plasma glucose and insulin sensitivity, and support weight loss when combined with calorie control. It is safe, non-stimulant, and clinically effective in both obese and overweight populations.

L-Tryptophan is an essential amino acid and the direct biochemical precursor to serotonin (5-HT) and melatonin. By enhancing central serotonin synthesis, tryptophan modulates appetite-regulating pathways in the hypothalamus, particularly through activation of 5-HT1B and 5-HT2C receptors. This neuromodulation reduces emotional eating, stress-induced cravings, and increases post-meal satisfaction — especially in individuals prone to carbohydrate-rich comfort food intake. Beyond its central effects, L-Tryptophan also influences peripheral satiety signaling. It stimulates the secretion of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), two key hormones that promote fullness and slow gastric emptying. Additionally, it increases the anorexigenic peptide YY (PYY) while decreasing ghrelin, the primary hormone responsible for hunger signaling. In clinical contexts, L-Tryptophan has been used to manage binge eating disorder, depressive hyperphagia, and night eating syndrome — highlighting its dual role in supporting both satiety and mood regulation.

The Affron® is a standardized saffron extract rich in crocin, safranal, and lepticrosalides — bioactive compounds that modulate mood and appetite through the serotonergic and dopaminergic systems. Clinical trials have shown that saffron supplementation reduces snacking frequency, compulsive eating, and emotional hunger. Its effects are thought to involve increased dopamine availability and serotonin reuptake inhibition, leading to enhanced mood and decreased need for food-based reward.

The Gymnema sylvestre is a tropical herb known for its dual-action effects on taste perception and glucose metabolism. Its active compounds, gymnemic acids, structurally resemble glucose and bind to sweet taste receptors on the tongue, temporarily suppressing the perception of sweetness. This blunting of sweet taste can reduce sugar cravings and hedonic eating behavior. At the intestinal level, gymnemic acids inhibit glucose transporters such as SGLT1, reducing the absorption of dietary glucose and thereby lowering postprandial blood glucose levels. Clinical studies have demonstrated that Gymnema supplementation can reduce sugar intake, improve glycemic control, and support weight loss, particularly in individuals with insulin resistance, prediabetes, or type 2 diabetes.

Piperine.Is a potent bioenhancer that inhibits metabolic enzymes such as CYP3A4 and P-glycoprotein, thereby increasing the bioavailability and plasma levels of specific compounds.

References

- Mirzababaei A, Zandkarimi R, Moradi S, et al. The effect of Glucomannan on fasting and postprandial blood glucose in adults: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord. 2022 Feb 27;21(1):1055-1063. doi: 10.1007/s40200-022-00993-6.

- Au-Yeung F, Jovanovski E, Jenkins AL, Zurbau A, Ho HVT, Vuksan V. The effects of gelled konjac glucomannan fibre on appetite and energy intake in healthy individuals: a randomised cross-over trial. Br J Nutr. 2018 Jan;119(1):109-116. doi: 10.1017/S0007114517003233.

- Meyer-Gerspach AC, Häfliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wölnerhanssen B. Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One. 2016 Nov 22;11(11):e0166758. doi: 10.1371/journal.pone.0166758.

- Hajishafiee M, Ullrich SS, Fitzgerald PC, et al. Suppression of Energy Intake by Intragastric l-Tryptophan in Lean and Obese Men: Relations with Appetite Perceptions and Circulating Cholecystokinin and Tryptophan. J Nutr. 2021 Oct 1;151(10):2932-2941. doi: 10.1093/jn/nxab218.

- Zhu Y, Yin L, Liu Q, Guan Y, Nie S, Zhu Y, Mo F. Tryptophan metabolic pathway plays a key role in the stress-induced emotional eating. Curr Res Food Sci. 2024 Apr 26;8:100754. doi: 10.1016/j.crfs.2024.100754.

- Steinert RE, Luscombe-Marsh ND, Little TJ, Standfield S, Otto B, Horowitz M, Feinle-Bisset C. Effects of intraduodenal infusion of L-tryptophan on ad libitum eating, antropyloroduodenal motility, glycemia, insulinemia, and gut peptide secretion in healthy men. J Clin Endocrinol Metab. 2014 Sep;99(9):3275-84. doi: 10.1210/jc.2014-1943.

- Steinert RE, Ullrich SS, Geary N, Asarian L, Bueter M, Horowitz M, Feinle-Bisset C. Comparative effects of intraduodenal amino acid infusions on food intake and gut hormone release in healthy males. Physiol Rep. 2017 Nov;5(21):e13492. doi: 10.14814/phy2.13492.

- Lu C, Ke L, Li J, et al. Saffron (Crocus sativus L.) and health outcomes: a meta-research review of meta-analyses and an evidence mapping study. Phytomedicine. 2021 Oct;91:153699. doi: 10.1016/j.phymed.2021.153699.

- Hausenblas HA, Heekin K, Mutchie HL, Anton S. A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. J Integr Med. 2015 Jul;13(4):231-40. doi: 10.1016/S2095-4964(15)60176-5.

- Gout B, Bourges C, Paineau-Dubreuil S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutr Res. 2010 May;30(5):305-13. doi: 10.1016/j.nutres.2010.04.008.

- Devangan S, Varghese B, Johny E, Gurram S, Adela R. The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Phytother Res. 2021 Dec;35(12):6802-6812. doi: 10.1002/ptr.7265.

- Zamani M, Ashtary-Larky D, Nosratabadi S, et al. The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis. Phytother Res. 2023 Mar;37(3):949-964. doi: 10.1002/ptr.7585.

- Woodgate DE, Conquer JA. Effects of a stimulant-free dietary supplement on body weight and fat loss in obese adults: a six-week exploratory study. Curr Ther Res Clin Exp. 2003 Apr;64(4):248-62. doi: 10.1016/S0011-393X(03)00058-4.

- Wh H, R K, C D, I N, E S, A A. The effect of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth. Appetite. 2025 Mar 1;207:107871. doi: 10.1016/j.appet.2025.107871.